SPRAVATO can cause serious side effects, including anxiety, dissociation, dizziness, nausea, sedation, spinning sensations, increased blood pressure, reduced sense of touch and sensation, lack of energy, vomiting, and feeling drunk. These common side effects usually occur right after taking SPRAVATO and then disappear the same day. Dissociation means feeling disconnected from yourself, your thoughts, feelings, space, and time. SPRAVATO may cause a temporary increase in blood pressure that can last about four hours after a dose. Your healthcare provider will check your blood pressure before you take SPRAVATO and for at least two hours after. Tell your provider immediately if you experience chest pain, shortness of breath, sudden severe headache, a change in vision, or seizures after taking SPRAVATO. Tell your provider if you have difficulty thinking or remembering, develop trouble urinating, have a frequent or urgent need to urinate, urinate frequently at night, or have pain when urinating.